In this Review, Tom Foulkes and John N. Wood focus on genetic approaches to the mechanisms involved in activating nociceptive neurons, human genetics of pain perception, and genetic validation of pain targets leading to new drugs.
These results demonstrate that three related VIM family proteins have overlapping functions in the MET1-mediated CpG methylation pathway
To identify mechanisms that regulate mammalian longevity, the authors quantified the expression parallels of a number of long-lived mice that show delayed aging and DNA repair mutants that age and die prematurely.
These results indicate that a noncoding RNA gene may contribute to independent transcriptional regulation in the genome.
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Pathogens; PLoS ONE; PLoS Neglected Tropical Diseases
PLoS Biology; PLoS Medicine; PLoS Computational Biology; PLoS Neglected Tropical Diseases
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